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Transient global amnesia vs tia10/13/2023 ![]() ![]() This study suggests that, in this large cohort of patients with TGA, recurrent TGA was associated with earlier age at the time of first TGA episode and higher prevalence of both personal and family history of migraine compared with isolated cases. Several studies showed differences in vascular risk factors between TGA compared to transient ischemic attack (TIA) or healthy controls with varying results. A family history of TGA was identified in 12 individuals (1.3%) with a single episode of TGA and 4 individuals (2.8%) with recurrent episodes of TGA. Objective: Transient global amnesia (TGA) is defined by an acute memory disturbance of unclear etiology for a period of <24 h. Acute and subacute temporal lobe abnormalities on results of magnetic resonance imaging were seen rarely and did not require intervention. There were no electroencephalographic findings associated with increased risk of TGA recurrence. 001), and a family history of migraine in 167 individuals (18.5%) with a single episode of TGA and 44 individuals (30.8%) with recurrent episodes of TGA (P =. There was a personal history of migraine in 180 individuals (20.0%) with a single episode of TGA and 52 individuals (36.4%) with recurrent episodes of TGA (P <. The mean (SD) age at first episode of TGA was 65.2 (10.0) years for individuals with a single episode vs 58.8 (10.3) years for those with recurrent episodes (P <. The number of recurrences ranged from 1 to 9, with 137 individuals (95.8%) having 3 or fewer recurrences. The 2 groups were similar in age at inclusion, sex, identifiable triggers, and duration of anterograde amnesia. A total of 901 patients (86.3%) had a single episode of TGA and 143 (13.7%) had recurrent episodes of TGA. Of 1044 included patients, 575 (55.1%) were male, and the mean (SD) age at inclusion was 75.0 (11.5) years. The main outcome measure was TGA recurrence. A total of 1491 cases were reviewed and 1044 met diagnostic inclusion criteria for TGA, with the remainder excluded owing to indeterminate or alternate diagnoses or limited information available in the medical record.ĭemographics, precipitating factors, migraine history, imaging and electrodiagnostic findings, and family history of TGA were collected. This retrospective cohort study involved medical record review of patients with isolated or recurrent TGA presenting to the Mayo Clinic in Rochester, Minnesota, between August 1, 1992, and February 28, 2018. ![]() ![]() To examine risk factors for the recurrence of TGA. However, recurrence rates vary considerably among studies and there are no known risk factors for TGA. The likelihood of stroke after TGA was lower than after seizure (hazard ratio, 0.57 95% CI, 0.44-0.76) or transient ischemic attack (hazard ratio, 0.27 95% CI, 0.20-0.35).Ĭompared with patients diagnosed with migraine or seizure, patients diagnosed with TGA do not seem to face a heightened risk of stroke.Transient global amnesia (TGA) is usually considered a benign event with a low recurrence rate. After adjustment for demographic characteristics and stroke risk factors, TGA was not associated with stroke risk when compared with migraine (hazard ratio, 0.82 95% CI, 0.61-1.10). #TRANSIENT GLOBAL AMNESIA VS TIA CODE#International Classification of Diseases, 9th Edition, Clinical Modification code 437.7 had a sensitivity of 86% and a specificity of 95% for TGA. Kaplan-Meier statistics were used to calculate rates of ischemic stroke, and Cox proportional hazards analyses were used to compare stroke risk among the 4 exposure groups while controlling for traditional stroke risk factors. Patients with a primary discharge diagnosis of migraine, seizure, or transient ischemic attack were included as controls. Therefore, we examined stroke risk after TGA in a population-based cohort.Īfter performing chart review at our institution to validate the International Classification of Diseases, 9th Edition, Clinical Modification diagnosis code for TGA, we used administrative claims data to identify all patients discharged from nonfederal California emergency departments or acute care hospitals between 20 with a primary discharge diagnosis of TGA. Whether transient global amnesia (TGA) represents an arterial insult that heralds ischemic stroke remains unclear. ![]()
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